1. Prevalence of CHDs:

2. Brown, KL et al: “Delayed diagnosis of CHD and outcome in neonates.” © 2006 Heart-British Medical Journal:

3. Information on effects of delayed diagnosis of CHD. © 2010, Corience. Independent European Network on CHDs :

4. Jaeggi ,ET et all: Outcome of pre versus postnatally diagnosed major congenital heart disease UOG 2001:

5. Gembruch, U, et al. First-trimester diagnosis of fetal congenital heart disease by transvaginal two-dimensional and Doppler echocardiography. Obstetrics & Gynecology 75.3, Part 2 (1990): 496-498.

6. Dolkart l. and Reimers F.: Transvaginal fetal echocardiography in early pregnancy: Norma ve data. Am J Obstet Gynecol 1991 165: 3 688–691

7. Bronshtein, M., et al. Fetal Cardiac Abnormalities Detected by Transvaginal Sonography at 12-16 Weeks Gesta on. Obstetrics and Gynecology 78.3 (1991): 374-378

8. Bronshtein M., et al: Early Ultrasound Diagnosis of Fetal Congenital Heart Defects in High-Risk and Low-Risk Pregnancies. Obstetrics and Gynecology, 1993 82;2, 225-229

9. Blaas, H-G., et al. Early development of the abdominal wall, stomach and heart from 7 to 12 weeks of gestation: a longitudinal ultrasound study. Ultrasound Obstet Gynecol 1995 6:1 240-249.

10. Gembruch U.: Prenatal diagnosis of congenital heart disease. Prenatal diagnosis 1997: 1283-1298.;2-T/ful12

11. Rottem S. IRONFAN: new time-oriented malforma on work-up and classification of fetal anomalies. Ultrasound Obstet Gynecol (1997): 10:6 373-374.

12. Shapiro I., et al: Fetal cardiac measurements derived by transvaginal and transabdominal cross-sectional echocardiography from 14 weeks of gestation to term. Ultrasound Obstet Gynecol 1998 12: 6: 404–418

13. Leiva M., et al: Fetal cardiac development and hemodynamics in the first trimester. Ultrasound Obstet Gynecol 1999 14:3 169–174

14. Gembruch U., et al: Biometry of the Fetal Heart between 10 and 17 Weeks of Gestation Fetal Diagn Ther 2000 15:1 20–31

15. Homberger L.K and Barea C: Diagnosis, Natural History, and Outcome of Fetal Heart Disease. Seminars in Thoracic and Cardiovascular Surgery: Pediatric Cardiac Surgery Annual, Vol 4;1 (2001); 22-24

16. Bronshtein M. and Zimmer E. The sonographic approach to the detection of fetal cardiac anomalies in early pregnancy. Ultrasound Obstet Gynecol. 2002:4, 360-5.

17. Haak ML., et al: How successful is fetal echocardiographic examina on in the first trimester of pregnancy? Ultrasound Obstet Gynecol. 2002 20:1, 9-13

18. Haak ML et al: Cardiac malformations in first-trimester fetuses with increased nuchal translucency: ultrasound diagnosis and postmortem morphology. Ultrasound Obstet Gynecol 2002 20:1; 14–21

19. Goncalves L., et al : Four-dimensional ultrasonography of the fetal heart with spatiotemporal image correla on Am J Obstet Gynecol. 2003 189:6.1792-802.

20. Lopes L., et al: Structural and functional cardiac abnormalities iden fied prior to 16 weeks’ gestation in fetuses with increased nuchal translucency. Ultrasound Obstet Gynecol 2003 22:5 470-8.

21. Smrcek, J., et al. The evaluation of cardiac biometry in major cardiac defects detected in early pregnancy. Archives of gynecology and obstetrics 268.2 (2003): 94-101.

22. Trines J., and Hornberger L.K.: Evolution of Congenital Disease in Utero. Pediatric Cardiology 2004, Volume 25;3; 287–298

23. McAuliffe F., et all: Early fetal echocardiography–a reliable prenatal diagnosis tool. Am J Obstet Gynecol 2005 193:3 Pt 2:1253-9.

24. Vimpelli T., et all: Fetal echocardiography during routine first-trimester screening: a feasibility study in an unselected population. Prenatal Diagnosis 2006 26:5 475–482

25. Carvahlo J.: Fetal heart scanning in the first trimester. Prenatal Diagnosis 2014. 24, 1060–1067

26. Rima Bader, Lisa Hornberger and James Huhta (Authors): The Perinatal Cardiology Handbook. Elsevier 2008

27. Moon-Grady A et al: Can a complete fetal echo cardiogram be performed at 12 to 16 weeks gestation? J Am Soc Echocardiography. 2012:

28. Rottem S., et al: Ultrasound based natural history and time-oriented distribution of 536 fetal anomalies. Ultrasound Obstet Gynecol, 2012 40:S1 64-65

29. Mirza F., et all: Early fetal echocardiography: ready for prime time? Am J Perinatol 2012 29:4. 313-8

30. AIUM Practice Guidelines for the Performance of Fetal Echocardiography, 2013: Fetal Echocardiography in Risk Population; Multi-Societies Guidelines

31. Ailes EC et al.,: Prenatal diagnosis of nonsyndromic congenital heart defects. Prenatal Diagnosis 2014 34:3 214-222

32. Espinoza J et al.,: Collaborative Study of 4-Dimensional Fetal Echocardiography in the First Trimester of Pregnancy. Journal of Ultrasound in Medicine 2014 33:6 1079–1084

33. Holland B, et al: Prenatal diagnosis of critical congenital heart disease reduces risk of death from cardiovascular compromise prior to planned neonatal cardiac surgery: a meta-analysis. Ultrasound Obstet Gynecol 2015:;jsessionid=63CB29E4CC58CA568742B49B6F5983B8.f03t02

34. Jørgensen D, et all: Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening. Prenat Diagn 2015

35. Wloch A, et all: Atrial dominance in the human embryonic heart: a study of cardiac function at 6–10 weeks of gestation. Ultrasound Obstet Gynecol

36. Rottem S., et al: Markers and intelligent agent driven early fetal echocardiography in lieu of the conventional views-focused scanning method. Ultrasound Obstet Gynecol 2016 48:S1, 293

37. Rottem S., et al.: A novel customizable sensitivity and specificity driven standardization of early fetal echocardiography by TVS (transvaginal sonography). Ultrasound Obstet Gynecol 2016 48:S1, 294

38. Rottem S., et al Contribution of morphologic and biometric markers to detection of 22 congenital heart defects (CHDs) by transvaginal sonography at 9–14 weeks of gestation. Ultrasound Obstet Gynecol 2016 48:S1, 118

39. Hutchinson D., et al: First-Trimester Fetal Echocardiography: Identification of Cardiac Structures for Screening from 6 to 13 Weeks’ Gestational Age JASE 2017

40. Zhang Y et all: Observed Prevalence of Congenital Heart Defects From a Surveillance Study in China. JUM 2011

41. Chen X., et al: A national survey of fetal congenital heart diseases in China. Ultrasound Obstet Gynecol 2015 46-S1 26

42. Mei Lim J., et all: Cerebral oxygen delivery is reduced in newborns with congenital heart disease. The Journal of Thoracic and Cardiovascular Surgery, 2016 152: 1095-1103

43. New Screening Test Detects Congenital Heart Defects in Early Pregnancy.

44. Eckart Zitzler, Kalyanmoy Deb, Lothat Thiele (Authors) Comparison of Multiobjective Evolutionary Algorithms: Empirical Results- Evolutionary computation, 2000- MIT Press

45. Woods D., et al: Can We Ever Escape from Data Overload? A Cognitive Systems Diagnosis. Cognition, Technology and Work Springer 2002. 4:1 22–36

46. Michael Wooldridge (Author): Introduction to MultiAgent Systems, 2nd Edition, Willey 2009

47. Ian Witten, Eibe Frank, Mark Hall, Christopher Pal (Authors): Data Mining 4th Edition: Practical Machine Learning Tools and Techniques. Morgann Kaufmann 2016

48. Macedonia C. et al: Advanced Research and Data Methods in Women’s Health: Big Data Analytics, Adaptive Studies, and the Road Ahead. Ask the Experts Series. Obstetrics and Gynecology 2017

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